A woman weighing 600 pounds has spent the past ten years of her life in bed and dependent on her husband, and a doctor in Texas is her only hope.

A 51-year-old's addiction to food has resulted in her weighing almost 700 pounds, leaving her son little option but to be her primary caretaker.

A 24-year-old woman is approaching 700 pounds, but though her future depends on her losing weight, her husband fears she will leave him if she does.

Twins Kandi and Brandi fear losing each other to obesity and a serious event during weight loss surgery may separate them forever.

Due to her weight of 670 pounds, Ashley and her husband are forced to move into her parents' home; Ashley hopes weight-loss surgery can turn her life around.

Erica weighs 661-pounds and regrets not keeping a promise she made to her mother, but due to her previous shortcomings, her siblings are hesitant to help out.

Cynthia weighs 610-pounds and is a single mother with five children, but she faces emotions and challenges in her life when she thinks about her death.

Doug turns to food after he overcomes a dependence on drugs and alcohol, but he must gain control of his eating habits in order to save his life and marriage.

Diana weighs 620-pounds and is desperate to overcome her food addiction, which leads her to follow the lead of her niece to embark on a weight loss journey.

James faces several struggles from his 791 pound weight, which includes him being confined to his bed, unable to stand and is almost not able to move his legs.