Nicole weighs over 700 pounds and is close to leaving her two young children without a mother, so she turns to a doctor's diet program.

Though a man is only 30, he's lost his job, he's housebound and his life is falling apart due to his 800 pound body, so he must find the strength to change.

A 42-year-old woman must face the possibility of her early death due to her obesity and struggles to be an active part of her son's and partner's lives.

Due to her weight of over 600-pounds, Kristen tries to gain control of her obesity, but she faces the danger of losing her troubled son.

Michael's 632-pound body causes him to be dependent on his family, but the husband and father runs the risk of losing everything if he fails to face his issues.

Tanisha is desperate to continue living for her kids and avoid going down the same tragic path as her mother, who died at 50-years-old due to extreme obesity.

Due to the fact that the majority of Tracey's weight resides in her malformed legs, she suffers from a chronic condition, lymphedema.

Two brothers almost weigh 1,400 pounds combined, but although they don't get along with each other, their father takes them to see a doctor.

Although two brothers are a year into a weight loss program, one remains noncompliant, while the other sets his sights on a career instead of his diet.

Lee and Rena originally met and fell in love at a bariatric rehab center, but continue to struggle with both health and emotional issues.