James is suspected of cheating as he continues to gain weight and suffers life-threatening illnesses; Cynthia continues to lose weight at her own pace.

Melissa is overwhelmed with four children, a suffering marriage and pregnancy; Ashley encounters problems on her weight loss journey.

Christina's weight loss has begun causing problems, and her life has become endangered because of it; Paula needs surgery after losing 300 pounds.

Brittani has lost over 400 lbs. Will she and Bill start to plan to expand their family? Plus, after leaving her husband, Lupe is finally ready to make changes.

Sean must learn to cope with recent tragedies or risk losing his progress; Dottie tries to spend more time with her family despite her body pains.

Charity tries to repair her fractured relationship with Charly. Milla goes outside for the first time in five months as she aims to qualify for surgery.

Doug has lost over 200 pounds and is more involved with his family life. He is now an example of healthy habits, but eating disorders threaten his progress.

Pauline's self-destructive behavior continues to be a problem; Chad strives to be a better father and husband as he continues his journey.

Brothers Steven and Justin's lives are chronicled as they attempt to lose extra weight and thereby change their lives for the better.

A woman continues to struggle with her weight loss journey after a year of trying to lose weight, and she realizes that she is running out of treatment options.